6-(Bromomethyl)-2,4-diaminopteridine hydrobromide

Details 6-(Bromomethyl)-2,4-diaminopteridine hydrobromide 6-(Bromomethyl)-2,4-diaminopteridine hydrobromide

1977-04-11

1978-03-07

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D47508

Patent

active

040779572

ABSTRACT:
A pteridine compound having the formula of 6-(bromomethyl)-2,4-diaminopteridine hydrobromide. 2,4-diamino-6-pteridine-methanol.HBr is reacted with triphenylphosphine dibromide or phosphorus tribromide to form 6-(bromomethyl)-2,4-diaminopteridine hydrobromide. The bromine atom in the molecule can then be replaced with the functional group, N-[4-(methylamino)-benzoyl]-L-glutamic acid in the case of methotrexate and N-(4-aminobenzoyl)-L-glutamic acid in the case of aminopterin.

REFERENCES:
patent: 2710866 (1955-06-01), Caprara et al.
patent: 3242178 (1966-03-01), Elion
Farquhar et al., J. Med. Chem., 15, 567-569 (1972).
Piper et al., J. Heterocyclic Chem., 11(2), 279-280 (1974).

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