6-Bromocholesterol derivatives

Details 6-Bromocholesterol derivatives 6-Bromocholesterol derivatives

1982-01-15

1984-02-07

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 2603972, 250303, A61K 4902, A61K 4300

Patent

active

044303211

ABSTRACT:
Novel 6-bromo derivatives of cholesterol have the formula ##STR1## Such compounds are prepared from the known 6-iodocholesterol by treatment with cuprous bromide.These compounds, labelled with radioisotopes of Br-82 or Br-77, are localized in the adrenal, mammary and ovary tissue of female mammals and in the adrenal or prostate tissue of males when administered to such individuals. This provides a method for imaging adrenal, ovary or prostate tissue which is superior to use of the prior art 6-iodo-cholesterol.

REFERENCES:
patent: 4083947 (1978-04-01), Monks
patent: 4222887 (1980-09-01), Matsufuji
patent: 4256727 (1981-03-01), Triplett et al.
Fukushi, Kiyoshi, J. of Labelled Compounds and Radiopharmaceuticals, vol. XVI (1) pp. 49-51 (1979).
Kojima, M. et al., J. of Labelled Compounds and Radiopharmaceuticals, vol. XIII (2), pp. 443-451, and p. 227 (1977).
Kojima, M. et al., Steroids, vol. 29, No. 4, pp. 443-451 (1977).

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