6 .beta.-Thiomorphine derivatives

Details 6 .beta.-Thiomorphine derivatives 6 .beta.-Thiomorphine derivatives

1991-06-10

1993-06-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 44, A61K 31485, C07D48900

Patent

active

052198618

ABSTRACT:
A novel morphine derivative represented by the following general formula: ##STR1## wherein R.sub.1 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group;

REFERENCES:
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Chemical Abstracts, vol. 109, No. 21, (Nov. 1988), p. 49, Column 1, abstract No. 183385r, Takayanagi et al.
Chemical and Pharaceutical Bulletin, "Design and Synthesis of Sulfur-Containing Morphine and an Opioid Receptor Probe", vol. 36, No. 6, (1988), pp. 2282-2285, Fujii et al.
Chemical Abstracts, vol. 70, No. 19, (May 1969), p. 367, column 2, abstract No. 88020k, Bognar et al.
Takayanagi et al., Arch. Int. Pharmacodyn. Ther. 1988, vol. 294, pp. 71-84 (1988).
Burger's Medicinal Chemistry, 4th ed., Wolff, ed., John Wiley & Sons, New York, A Wiley-Interscience publication 1981, pp. 711-712.
Takayanagi et al., Gen. Pharmac., vol. 21, No. 5, pp. 605-611 (1990), Chemical Abstracts vol. 113; 204260w (1990).
Takayanagi et al., Gen. Pharmac. 1990, 21(4) pp. 541-546 Chemical Abstracts, vol. 113:109138d (1990).

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