6-.beta.-Substituted penicillanic acids as .beta.-lactamase inhi

Details 6-.beta.-Substituted penicillanic acids as .beta.-lactamase inhi 6-.beta.-Substituted penicillanic acids as .beta.-lactamase inhi

1984-02-27

1985-05-21

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424270, C07D49900, A61K 31425

Patent

active

045185301

ABSTRACT:
6-.beta.-Substituted penicillanic acids and derivatives thereof as useful enhancers of the effectiveness of several .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria, and 6-.beta.-substituted penicillanic acid derivatives wherein the carboxy group is protected by a conventional penicillin carboxy protecting group as useful intermediates leading to said synergistic agents. A process for converting 6,6-disubstituted penicillanic acid derivatives to the corresponding 6-.beta.-substituted penicillanic acid congeners.

REFERENCES:
patent: 4180506 (1979-12-01), Pratt
patent: 4203992 (1980-05-01), Koster et al.
patent: 4397783 (1983-08-01), Kellogg et al.
Loosemore and Pratt, Journal of Organic Chemistry, 43, 3611-3613, (1978).
Roets, Vlietinck and Vanderhaeghe, Journal of the Chemical Society, (London), Perkin I, 704, (1976).
Knott-Hunziker, Orlek, Sammes and Waley, Biochemical Journal, 177, 365, (1979).
Pratt and Loosemore, Proceedings of the National Academy of Sciences, U.S.A., vol. 75, pp. 4145-4149, (1978).

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