6-Azauracil derivatives as IL-5 inhibitors

Details 6-Azauracil derivatives as IL-5 inhibitors 6-Azauracil derivatives as IL-5 inhibitors

2005-10-04

2005-10-04

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S182000

Reexamination Certificate

active

06951857

ABSTRACT:
The present invention is concerned with the use of compounds of formulathe N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p represents 0, 1, 2 or 3; q represents 0, 1, 2, 3 or 4; R1represents hydrogen, C1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, mercapto, C1-6alkylthio, C3-7cycloalkyl, aryl or C1-6alkyl substituted with mono- or di(C1-6alkyl)amino, C1-6alkyloxy, aryl or Het; R2represents cyano or a radical of formula —C(═X)—Y—R5; wherein X represents O or S; Y represents O, S, NR6or a direct bond; R5represents hydrogen; C3-7cycloalkyl; aryl or optionally substituted C1-6alkyl; and where Y is a direct bond, R5may also be halo or Het; R3and R4each independently represents halo, haloC1-6alkyl, C1-6alkyl, hydroxy, C1-6alkyloxy, C1-6alkylcarbonyloxy, mercapto, C1-6alkylthio, C1-6alkylsulfonyl, C1-6alkylsulfinyl, haloC1-6alkylsulfonyl, aryl, cyano, nitro, amino, mono- and di(C1-6alkyl)amino or (C1-6alkylcarbonyl)amino; aryl represents phenyl or substituted phenyl; and Het represents an optionally substituted heterocycle; in the manufacture of a medicament useful for treating eosinophil-dependent inflammatory diseases. The invention also relates to novel compounds, their preparation and compositions comprising them.

REFERENCES:
patent: 3883527 (1975-05-01), Brennan
patent: 4631278 (1986-12-01), Boeckx et al.
patent: 4767760 (1988-08-01), Boeckx et al.
patent: 4931444 (1990-06-01), Van Wauwe et al.
patent: 5256631 (1993-10-01), Lindner et al.
patent: 0232932 (1987-08-01), None
patent: 476 439 (1992-03-01), None
patent: 737 672 (1996-10-01), None
patent: WO 94/14742 (1994-07-01), None
patent: WO 94/20446 (1994-09-01), None
patent: WO 96/31485 (1996-10-01), None
Carroll et al., J. Med. Chem. 1983, 26, 96-100.
Carr et al., Immunology, 1994, 91, 3652-3656.
Baggiolini et al., Immunology Today, 1994, 15(3), 127-133.
International Search Report for PCT Appln. No. PCT/EP98/04192.

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