6-azaindole thromboxane synthase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 81, 546 23, 546113, A61K 31435, C07D47104

Patent

active

054687578

ABSTRACT:
Selected acid functional 6-azaindole type derivatives effective as thromboxane synthase inhibitors having the formula (II): ##STR1## where n is an integer from zero to 3, m is an integer from zero to 2, R.sub.1 and R.sub.2 are monovalent radicals, --(L.sub.a)-- is a linking group of 4 to 8 chain atoms, and A is an acidic group.

REFERENCES:
patent: 4766129 (1988-08-01), Schnorrenberg et al.
Mahadevan et al., Tet. Letters vol. 49 (33), pp. 7337-7352 (Aug. 1993).
Dvorakova et al., Collection of Czech. Chem. Communications, pp. 1419-1428 (1993).

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