6-Aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepines

Details 6-Aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepines 6-Aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepines

1976-10-26

1978-08-29

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602948B, 2602949, 260295T, 260296H, A61K 3144, C07D47104

Patent

active

041104552

ABSTRACT:
There are produced 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-(1,4)-diazepines of the formula: ##STR1## wherein R.sub.1 is hydrogen, a halogen atom, an alkyl group with 1 to 6 carbon atoms, a hydroxy group, an alkoxy group with 1 to 6 carbon atoms, a mercapto group, an alkyl mercapto group having 1 to 6 carbon atoms, an alkylsulfoxido group with 1 to 6 carbon atoms, an alkyl sulfono group with 1 to 6 carbon atoms, an amino group, an aliphatic acylamino group with 2 to 6 carbon atoms, a monoalkylamino group with 1 to 6 carb0n atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms in the ring,
R.sub.2 is hydrogen, an alkyl group with 1 to 6 carbon atoms, a hydroxy group, an acyloxy group with 2 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms, a mercapto group, an alkylmercapto group with 1 to 6 carbon atoms, a halogen atom, an amino group, an aliphatic acylamino group with 2 to 6 carbon atoms, a monoalkylamino group with 1 to 6 carbon atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms in the ring,
R.sub.3 is hydrogen, an alkyl group with 1 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms or a halogen atom,
The structural part A--B is the group --N.dbd.N--, --CH.sub.2 --NH--, --CO--NR.sub.4, --C(SR.sub.5).dbd.N--, --C(OR.sub.5).dbd.N--, --C(NR.sub.5 R.sub.5).dbd.N--, or --CR.sub.6 .dbd.N--,
wherein R.sub.4 is hydrogen, an alkenyl group with 2 to 6 carbon atoms, an alkinyl group with 2 to 6 carbon atoms, a hydroxy-alkyl group with 1 to 6 carbon atoms, a ketoalkyl group with 1 to 6 atoms in the alkyl group, a cyanoalkyl group with 1 to 6 carbon atoms, an alkyl group with 1 to 6 carbon atoms, or an alkyl group of 1 to 6 carbon atoms substituted by an alkoxy group with 1 to 6 carbon atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms,
R.sub.5 is hydrogen or an alkyl group with 1 to 6 carbon atoms,
R.sub.6 is hydrogen, an alkyl group with 1 to 6 carbon atoms or a haloalkyl group with 1 to 6 carbon atoms,
And Y--Z is the group >CH.dbd.N--, >C.dbd.N(.fwdarw.O), >CH--NH-- or >CH--N(OH)-- and wherein R.sub.6 is other than alkyl if R.sub.1 is chlorine, R.sub.2 is hydrogen, R.sub.3 is hydrogen or halogen and Y-Z is the group >C.dbd.N--, their optical isomers and their pharmaceutically acceptable salts. The compounds have anticonvulsive properties.

REFERENCES:
patent: 4039551 (1977-08-01), Hester

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