6- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzo

Details 6- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzo 6- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzo

1989-09-25

1990-12-18

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549457, 549460, A61K 3134, C07D30791

Patent

active

049786792

ABSTRACT:
Positions 7- and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described.
These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful in the treatment of a variety of inflammatory conditions.

REFERENCES:
patent: 3317527 (1967-05-01), Skaletzky et al.
patent: 3496181 (1970-02-01), Skaletzky et al.
patent: 3803180 (1974-04-01), Berger et al.
patent: 3931288 (1976-01-01), Berger et al.
patent: 4857516 (1989-08-01), Terao et al.
K. Brannock et al., J. Org. Chem., 29, 2579, (1964).
W. J. Greenlee et al., Tetrahedron Lett. 24 pp. 4559-4560 (1983).
T. Takahashi et al., Tetrahedron Letters 23, pp. 4361-4364 (1982).
T. Takahashi et al., Tetrahedron Letters 24, pp. 3489-3492 (1983).
A. J. Birch et al., J. Chem. Soc. 1964, pp. 2932-2941.
A. J. Birch and V. H. Powell, Tetrahedron Letters 1970, 3467-3470.
V. H. Powell, Tetrahedron Letters 1970, pp. 3463-3466.

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