6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2

Details 6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2 6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2

1990-02-15

1991-06-04

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546272, 540200, 544333, C07D48704

Patent

active

050215663

ABSTRACT:
Disclosed are 6- and 6,6-disubstituted-3-substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carbo xylic acids (I): ##STR1## wherein R.sup.1 and R.sup.2 are, inter alia, independently selected from the group consisting of hydrogen (both are not hydrogen at the same time), substituted and unsubstituted: alkyl, aryl and aralkyl; X is halo, oxygen (the 2-3 bond is saturated and the species I exists as carboxylate salt or ester), or --OR wherein R is, inter alia, acyl, alkyl, or aralkyl. Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4234596 (1980-11-01), Christensen et al.
patent: 4260627 (1981-04-01), Christensen et al.
patent: 4310538 (1982-01-01), Christensen et al.
patent: 4318912 (1982-03-01), Christensen et al.
patent: 4357342 (1982-11-01), Christensen et al.
patent: 4369187 (1983-01-01), Christensen et al.
patent: 4424230 (1984-01-01), Christensen et al.
patent: 4530841 (1985-07-01), Christensen et al.
patent: 4539208 (1985-09-01), Kahan et al.

Affiliated with

Also associated with

Rating

6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1027809