6- and 6,6-Disubstituted-2-substituted-oxapen-2-em-3-carboxylic

Details 6- and 6,6-Disubstituted-2-substituted-oxapen-2-em-3-carboxylic 6- and 6,6-Disubstituted-2-substituted-oxapen-2-em-3-carboxylic

1979-10-10

1981-10-06

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26032647, 2602452R, 2602453, 260239A, 2602454, 2603474, 546256, 546270, 546328, 560193, 560196, 560146, 560 9, 549 72, 424272, 548253, 548125, C07D49804, C07D20508, A61K 3142, C07D40906

Patent

active

042935555

ABSTRACT:
Disclosed are 6- and 6,6-disubstituted-2-substituted-oxapen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein: R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, alkoxyl, aralkyl, aryl, heterocyclyl and heterocyclylalkyl; R is selected from hydrogen, --OR, --SR, --NR.sub.2, alkyl, aryl, aralkyl, heterocyclyl, or heterocyclylalkyl. Such compounds and their pharmaceutically acceptable salt, and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4172895 (1974-10-01), Christensen et al.
Cherry, Chem. Abs. 88, 190807f (1978).

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