6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carbo

Details 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carbo 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carbo

1981-03-18

1982-09-21

Lee, Mary C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239A, 546272, C09D48704

Patent

active

043506313

ABSTRACT:
Disclosed are 6- and 4-substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid esters and salts (I) which are useful in the preparation of 6-, 1- and 2-substituted carbapenem antibiotics. ##STR1## wherein R.sup.5 is a pharmaceutically acceptable ester moiety or a removable protecting group or an alkali or alkaline earth metal cation such as sodium or potassium and wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl and aralkyl.

REFERENCES:
patent: 4218462 (1980-08-01), Christensen et al.
patent: 4232036 (1980-11-01), Christensen et al.
patent: 4262010 (1981-04-01), Christensen et al.
patent: 4269772 (1981-05-01), Melello et al.
patent: 4273709 (1981-06-01), Christensen et al.
patent: 4282148 (1981-08-01), Liu et al.
patent: 4290947 (1981-09-01), Christensen et al.
patent: 4312871 (1982-01-01), Christensen et al.
Kametani et al., Heterocycles, vol. 14, pp. 1305-1308 (1980).

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