6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carb

Details 6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carb 6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carb

1990-02-15

1991-02-19

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540310, C07D48704, A61K 31495

Patent

active

049945688

ABSTRACT:
Disclosed are 6- and 4-substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid esters and salts (I) which are useful in the preparation of 6-, 1- and 2-substituted carbapenem antibiotics. ##STR1## wherein R.sup.5 is a pharmaceutically acceptable ester moiety or a removable protecting group or an alkali or alkaline earth metal cation such as sodium or potassium and wherein R.sup.1, R.sup.2, Rhu 3 and R.sup.4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl and aralkyl. Another embodiment disclosed is a group of compounds having the formula ##STR2## where X is a leaving group.

REFERENCES:
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patent: 4262010 (1981-04-01), Christensen et al.
patent: 4273709 (1981-06-01), Christensen et al.
patent: 4310538 (1982-01-01), Christensen et al.
patent: 4318912 (1982-03-01), Christensen et al.
patent: 4347355 (1982-08-01), Chu
patent: 4424230 (1982-01-01), Christensen et al.

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