6-Aminopenicillanic acid derivatives

Details 6-Aminopenicillanic acid derivatives 6-Aminopenicillanic acid derivatives

1972-11-06

1976-05-18

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, 2603067C, 424270, C07D49902, C07D49932

Patent

active

039577643

ABSTRACT:
The invention relates to hitherto unknown derivatives of 6-aminopenicillanic acids of the formula ##SPC1##
In which R.sub.1 and R.sub.2 are similar or different aliphatic, cycloaliphatic, aromatic or heterocyclic substituents linked directly or through alkyl groups to the nitrogen atom, or R.sub.1 and R.sub.2 together with the nitrogen atom form a heterocyclic ring, and R.sub.3 is a hydroxyl or substituted hydroxyl group; to pharmaceutically acceptable salts, and to methods for producing these new compounds having a strong antibacterial effect, especially on gram-negative bacteria, to pharmaceutical preparations in dosage unit forms containing the compounds of the invention solely, or in synergistic mixtures with penicillins, and to methods of treating patients with the dosage units.

REFERENCES:
patent: 3821198 (1974-06-01), Lee et al.
patent: 3855233 (1974-12-01), Dolfini et al.
Nature New Biology, Vol. 236, pp. 135-137, (1972).

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