6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-l

Details 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-l 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-l

1982-06-14

1984-01-24

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602452R, 424263, 424271, A61K 31545, A61K 3143, C07D49900

Patent

active

044276788

ABSTRACT:
beta-Lactamase inhibitors which are 6-alpha- and 6-beta(aminomethyl)pencillanic acid 1,1-dioxides which are substituted on amino nitrogen with benzyl, hydroxybenzyl, picolyl or phenethyl; pharmaceutically-acceptable salts thereof; conventional esters thereof hydrolyzable in vivo; pharmaceutical compositions thereof with conventional beta-lactam antibiotics; and a method of treating bacterial infections with said pharmaceutical compositions.

REFERENCES:
patent: 4207323 (1980-06-01), Beattie et al.
patent: 4234579 (1979-03-01), Barth
patent: 4237051 (1980-02-01), McCombie
patent: 4287181 (1981-09-01), Kellogg
Sheehan et al., J. Org. Chem., 42, pp. 4045-4048 (1977).

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