6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lac

Details 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lac 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lac

1984-02-27

1985-03-05

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

2602452R, 2602452L, 514210, C07D49900, A61K 31425

Patent

active

045030405

ABSTRACT:
Beta-lactamase inhibitors which are aminoacid esters of 6-alpha- and 6-beta-(hydroxymethyl)pencillanic acid 1,1-dioxides; pharmaceutically-acceptable salts thereof; conventional esters thereof which are hydrolyzable in vivo; bis-methanediol esters thereof; or mixed methanediol esters with said beta-lactamase inhibitors and sulbactam. Pharmaceutical compositions comprising said beta-lactamase inhibitors and a conventional beta-lactam antibiotic, said compositions useful in the treatment of bacterial infections. Compounds useful as intermediates in the synthesis of said beta-lactamase inhibitors. Antibacterial mixed bis-methanediol esters of said aminoacyloxymethyl penicillanic acid 1,1-dioxides and ampicillin or amoxicillin, also useful in the treatment of bacterial infections; and intermediates therefor.

REFERENCES:
patent: 4287181 (1981-09-01), Kellogg
patent: 4342768 (1982-08-01), Kellogg

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