Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-05-11
1993-06-29
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514300, 544127, 546118, C07D47104, A61K 31535, A61K 31435
Patent
active
052234991
ABSTRACT:
Substituted imidazo[4,5-b]pyridines of structural formula: ##STR1## are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
REFERENCES:
patent: 4722929 (1988-02-01), Austel et al.
patent: 5049565 (1991-09-01), Chen et al.
patent: 5053329 (1991-10-01), Chen et al.
patent: 5057522 (1991-10-01), Chen et al.
patent: 5066586 (1991-11-01), Chen et al.
patent: 5087702 (1992-02-01), Chen et al.
Chang et al., Two Angiotensin II Binding Sites In Rat Brain Revealed Using [.sup.125 I]SAR.sup.1,ILE.sup.8 -Angiotensin II And Selective Nonpeptide Antagonists, Biochem. and Biophy. Res. Comm., 171, pp. 813-817 (1990).
Stromberg, C. et al. Neuro. Report, 3; pp. 703-704 (1992).
Schiavone, M., et al., Hypertension, 17, No. 3, p. 425 (1991).
Gyurko, R. et al., Biochem. & Biophys. Research Communications, 186, No. 1 pp. 285-292 (1992).
Bottari, S. et al., Biochem. & Biophys. Research Communications, 183, No. 1 pp. 206-211 (1992).
Pratt, R. et al., Hypertension, 20, No. 3, p. 432 (1992).
Greenlee William J.
Kim Dooseop
Mantlo Nathan B.
Pastchett Arthur A.
Rivero Ralph A.
Camara Valerie J.
Dentz Bernard
DiPrima Joseph F.
Merck & Co. , Inc.
Nicholson William H.
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