6-amino substituted imidazo[4,5-bipyridines as angiotensin II an

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514300, 544127, 546118, C07D47104, A61K 31535, A61K 31435

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active

052234991

ABSTRACT:
Substituted imidazo[4,5-b]pyridines of structural formula: ##STR1## are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.

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Chang et al., Two Angiotensin II Binding Sites In Rat Brain Revealed Using [.sup.125 I]SAR.sup.1,ILE.sup.8 -Angiotensin II And Selective Nonpeptide Antagonists, Biochem. and Biophy. Res. Comm., 171, pp. 813-817 (1990).
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Bottari, S. et al., Biochem. & Biophys. Research Communications, 183, No. 1 pp. 206-211 (1992).
Pratt, R. et al., Hypertension, 20, No. 3, p. 432 (1992).

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