6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, antibac

Details 6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, antibac 6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, antibac

1980-06-24

1981-06-02

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546 17, 548147, 2602452R, C07D49976, A61K 3143, C07D49974, C07D49958

Patent

active

042711720

ABSTRACT:
6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, salts and esters thereof of the formula ##STR1## wherein R.sub.1 is hydrogen, benzyl or an alkali metal or ammonium ion and R.sub.2 is methyl, phenyl or benzyl and process for preparing the same.
These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to penicillins, besides own antibiotic activity with a broad antibacterial spectrum. Therefore, they are useful as antibacterials agents and as therapeutic agents for humans and for animals in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

REFERENCES:
patent: 4091027 (1978-05-01), Rodriguez et al.
patent: 4137236 (1979-01-01), Rodriguez et al.
patent: 4137628 (1979-02-01), Rodriguez et al.
patent: 4145343 (1979-03-01), Rodriguez et al.

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