6-Amino-isoproterenol

Details 6-Amino-isoproterenol 6-Amino-isoproterenol

1974-06-20

1976-04-13

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601127, 260285, 26029354, 260309, 2603191, 2603975, 260471A, 2605705C, 2605707, 424316, 424330, C07C 9122

Patent

active

039504220

ABSTRACT:
Biologically active substances having labile aryl groups can be converted to the corresponding aryl amine derivatives. The biologically active substances are reacted with a diazonium compound which optionally can be linked to a solid, inorganic carrier such as porous glass beads for ease of purification. The diazo reaction product is then reductively cleaved with a chemical reducing agent such as with hydrosulfite to yield the desired amine derivative. A preferred class of biologically active substances used herein is the catecholamines.

REFERENCES:
patent: 3410901 (1968-11-01), Kung et al.
Mannich, et al., Chemical Abstracts, Vol. 33, pp. 6273-6274, (1939).
Burger, Medicinal Chemistry, 3rd Ed., Part II, pp. 1244-1245, (1970).

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