6-amino anthracyclines, process for their preparation and use th

Details 6-amino anthracyclines, process for their preparation and use th 6-amino anthracyclines, process for their preparation and use th

1987-07-14

1990-01-02

Yarbrough, Amelia Burgess

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 64, A61K 3170, C07H 1524

Patent

active

048913600

ABSTRACT:
Anthracycline glycosides having the general formula (A): ##STR1## wherein R.sub.1 is hydrogen, hydroxy or methoxy; R.sub.2 is amino, R.sub.3 is hydrogen or hydroxy and X is hydrogen; and their pharmaceutically acceptable salts; are antitumor agents. The compounds are obtained by reduction of the corresponding 6-nitro derivatives with stannous chloride in presence of sodium acetate or with palladium or charcoal in presence of cyclohexene.

REFERENCES:
patent: 4348388 (1982-09-01), Garland et al.
Morrison et al., Organic Chemistry, 3rd ed., 1979, p. 734.

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