6-amino-6-desoxyfumagillols, production and use thereof

Details 6-amino-6-desoxyfumagillols, production and use thereof 6-amino-6-desoxyfumagillols, production and use thereof

1991-09-19

1994-02-22

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514409, 514444, 514462, 514475, 544 70, 544230, 546 15, 546207, 548147, 548407, 5483007, 549332, 549551, 549554, 549563, 549 60, A61K 3140, A61K 31445, A61K 31335, C07D30302

Patent

active

052887227

ABSTRACT:
The present invention relates to a compound of the formula: ##STR1## wherein R.sup.1 is 2-methyl-1-propenyl group or isobutyl group; R.sup.2 and R.sup.3 are each hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group or R.sup.2 and R.sup.3 may form a ring together with the adjacent nitrogen atom; and the bonding mark .about. represents an .alpha.-linkage or .beta.-linkage, or a salt thereof. The compound (I) of the present invention has, among others, angiogenesis inhibiting activity, cell-growth inhibiting activity and immune reaction inhibiting activity, thus being useful as medicines, etc.

REFERENCES:
J. A. DiPaolo, et al., Antibiotics Annual (1958-1959), pp. 541-546.
Journal of American Chem. Society, vol. 83, pp. 3096-3113 (1961).
The Journal of Antibiotics, vol. 41, pp. 999-1008 (1988).
Chemical Abstract, 106:176153y, 1987.

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