6-amino-2-naphthyl 4-gusnichinobenzoate derivatives and pharmace

Details 6-amino-2-naphthyl 4-gusnichinobenzoate derivatives and pharmace 6-amino-2-naphthyl 4-gusnichinobenzoate derivatives and pharmace

1988-07-11

1989-04-11

Gray, Bruce D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560 34, A61K 3124, C07C12912

Patent

active

048207306

ABSTRACT:
Amidine compounds of formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) ##STR2## or a reactive intermediate thereof and 6-amidino-2-naphthol of formula (III) ##STR3## or preferably an acid addition salt thereof.

REFERENCES:
patent: 4420619 (1983-12-01), Marxer
patent: 4454338 (1984-06-01), Fujii et al.
patent: 4532255 (1985-07-01), Fujii et al.
patent: 4598077 (1986-07-01), Fujii et al.
Animal and Clinical Pharmacologic Techniques in Drug Evaluation, Edited by Nodine & Siegler, Chapter 7, "Stages of Drug Evaluation in Man; General Principles of Experimental Design", by John H. Nodine, M.D., pp. 89-95, esp. p. 90, published 1964, Yearbook Medical Publishers, Inc., Chicago.
Webster's New Int'l Dictionary, Second Edition (1961), p. 562, "Congestion".
Dorland's Illustrated Medical Dictionary, Twenty-Sixth Edition (1981), p. 298, "Congestion".

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