6-amino-2-benzothiazolesulfonamide and topical treatment composi

Details 6-amino-2-benzothiazolesulfonamide and topical treatment composi 6-amino-2-benzothiazolesulfonamide and topical treatment composi

1985-04-04

1990-12-04

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514913, 548166, A61K 31425, C07D27762, C07D27768, C07D27776

Patent

active

049754483

ABSTRACT:
A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-amino-2-benzothiazolesulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-amino-2-benzothiazolesulfonamide compound.

REFERENCES:
patent: 4499103 (1985-02-01), de Solmo
Chem. Abst. 102: 137644(2)(1985) Lewis et al.
Chem. Abst. 102: 197524(c)(1985) Eller et al.

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