6-Amido-3-substitu ted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-

Details 6-Amido-3-substitu ted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one- 6-Amido-3-substitu ted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-

1978-07-24

1980-08-12

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

260239A, 26032625, 2602452R, 42424854, 424250, 424263, 424267, 424269, 424270, 424274, 544 90, 544 96, 544144, 544333, 544355, 546174, 546200, 546256, 546272, 548 1336, 556407, C07D48704, A61K 3140, A61K 31495

Patent

active

042174538

ABSTRACT:
Disclosed are 6-amido-3-substituted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxyli c acids (I): ##STR1## wherein R.sup.1 is hydrogen or acyl; and R' and R" are independently selected from the group consisting of: hydrogen, substituted and unsubstituted: alkyl and aralkyl, or together form a substituted or unsubstituted cyclic group. Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 3971776 (1976-07-01), Cirmarusti et al.

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