Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1982-03-01
1983-06-14
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
2602391, 2602452R, 424263, 424270, 424271, A61K 3167, A61K 3143, C07D27702, C07D49944
Patent
active
043883109
ABSTRACT:
Disclosed are 6-amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids (I) which are useful as antibiotics and as intermediates in the synthesis of substituted pen-2-em-3-carboxylic acids: ##STR1## wherein: R.sup.1 is H or acyl; R.sup.2 is hydrogen or methoxyl; R.sup.3 is alkyl having from 1-6 carbon atoms; phenylalkyl having 7-12 carbon atoms; and cycloalkyl having 3-6 carbon atoms; and R.sup.4 is hydrogen, a removable protecting group or a pharmaceutically acceptable salt or ester moiety.
REFERENCES:
patent: 4164497 (1979-08-01), Kamiya et al.
patent: 4215124 (1980-07-01), Christensen et al.
patent: 4255330 (1981-03-01), Christensen et al.
Tetrahedron Letters, vol. 23, No. 8, pp. 897-900, (1982).
Christensen Burton G.
DiNinno Frank P.
Muthard David A.
Ratcliffe Ronald W.
Clarke Vera C.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Speer Raymond M.
Trousof Natalie
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