6.alpha.-Methylprednisolone derivatives

Details 6.alpha.-Methylprednisolone derivatives 6.alpha.-Methylprednisolone derivatives

1983-05-27

1986-01-28

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

26039745, 26023955D, A61K 3156

Patent

active

045671729

ABSTRACT:
A 6.alpha.-methylprednisolone derivative of the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom or stands for the grouping ##STR2## where R.sup.3 is a straight or once-branched chain C.sub.1-4 alkyl group, a phenyl group or a lower alkoxy- or alkylthio-methyl group, and R.sup.2 is a straight or once-branched chain C.sub.1-4 alkyl group, a phenyl group or a lower alkoxy- or alkylthio-methyl group, with the proviso that when R.sup.2 is ethyl group, R.sup.1 should not be a hydrogen atom or R.sup.3 should not be ethyl group. This compound exhibits a strong local antiinflammatory effect and is, therefore, useful as a harmless external antiinflammatory drug for various dermal disorders and also as an antiallergic drug for treating asthma and the like allergic diseases.

REFERENCES:
patent: 3312590 (1967-04-01), Elks et al.
patent: 4343799 (1982-08-01), Heckler
patent: 4358445 (1982-11-01), MacDonald
patent: 4435390 (1984-03-01), Annen et al.
Chemical Abstracts 99(5), Par. 38,713s, Abstract of Eur. Pat. Appl. 72,547, dated Feb. 23, 1983.

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