6-(.alpha.-Hydroxy ethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-

Details 6-(.alpha.-Hydroxy ethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2- 6-(.alpha.-Hydroxy ethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-

1978-05-08

1980-04-01

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

2602452R, 2602452T, 2603262R, 26032614R, 26032625, 26032631, 544239, 544316, 544353, 546174, 546275, 548336, C07D48704, A61K 3140

Patent

active

041962117

ABSTRACT:
Disclosed are 6-(.alpha.-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and its 2,3-dihydro analogue, 6-(.alpha.-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. Such compounds and their pharmaceutically acceptable salt, ester, ether and aide derivatives (derivatives involving both the secondary alcohol and the carboxyl group) are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
Fieser et al., Advanced Organic Chemistry; p. 310, (1961).
Wong et al., J.A.C.S. vol. 99, pp. 2823-2824, (1977).
Bose et al., J. Org. Chem. vol. 39, pp. 115-116, (1974).

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