6 Alpha, 6 beta-difluoro-etianic acid derivatives

Details 6 Alpha, 6 beta-difluoro-etianic acid derivatives 6 Alpha, 6 beta-difluoro-etianic acid derivatives

1978-04-05

1980-04-15

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603971, A61K 3156

Patent

active

041984048

ABSTRACT:
Certain 3-ketoandrost-4-ene and 3-ketoandrosta-1,4-diene 17 beta-carboxylic acids and esters substituted at the 6 alpha and 6 beta positions with fluorine substituents are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9 alpha position with fluoro, chloro or bromo; substituted at the 11 with a keto, a beta-hydroxy or a beta-chloro (the latter only when there is a 9 alpha-chloro); substituted at 16 alpha (or 16 beta) with methyl or hydrogen when there is a 17 alpha-hydroxy (or an ester).

REFERENCES:
patent: 3546215 (1970-12-01), Fried
patent: 4093721 (1978-06-01), Phillipps et al.

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