6-Alkylidene 10 .beta.-alkynylestrene derivatives and pharmaceut

Details 6-Alkylidene 10 .beta.-alkynylestrene derivatives and pharmaceut 6-Alkylidene 10 .beta.-alkynylestrene derivatives and pharmaceut

1986-12-15

1989-02-28

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

2603973, A61K 3156, C07J 100

Patent

active

048085782

ABSTRACT:
The invention relates to 6-substituted 10.beta.-alkynylestrene derivatives wherein the 6 substituent is amino, azido, halogen or an alkylidene group and to corresponding 6,7-dihalo analogs.
The invention provides also a process for the preparation of the above compounds and pharmaceutical compositions containing same.
The compounds of the invention are useful aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors and prostatic hyperplasia.

REFERENCES:
patent: 2744120 (1956-05-01), Fried et al.
patent: 4289762 (1981-09-01), Metcalf et al.
patent: 4322416 (1982-03-01), Metcalf et al.
patent: 4446071 (1984-05-01), Varna

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