6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyrid

Details 6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyrid 6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyrid

1983-01-31

1985-05-14

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546288, 546301, 514344, C07D21142, C07D21186, A61K 3144

Patent

active

045171920

ABSTRACT:
3-Q-5-[4-(R'-X)phenyl]-6-R-2(1H)-pyridinones (I), where R and R' are each methyl or ethyl, X is sulfinyl when Q is hydrogen or cyano, or X is sulfonyl when Q is cyano, their preparation and cardiotonic use are shown. Also shown are intermediates 5-[4-(R'-thio)phenyl]-6-R-2(1H)-pyridinones (II) and also corresponding 3-cyano intermediates.

REFERENCES:
patent: 3655679 (1972-04-01), Shen et al.
patent: 3718743 (1973-02-01), Shen et al.
patent: 4276293 (1981-06-01), Lesher et al.
patent: 4312875 (1982-01-01), Lesher et al.
patent: 4313951 (1982-02-01), Lesher et al.

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