6-alkoxy-pyrido-pyrimidines

Details 6-alkoxy-pyrido-pyrimidines 6-alkoxy-pyrido-pyrimidines

2006-09-12

2006-09-12

Wilson, James O. (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S258100, C544S279000, C546S112000

Reexamination Certificate

active

07105525

ABSTRACT:
The present invention provides compounds of the Formula I:wherein R1is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1is O, NH, N(alkyl), S or —C(═O), Z is N or CH; and R2and R3are as defined herein, pharmaceutical compositions comprising same, and methods for their use.

REFERENCES:
patent: 4215216 (1980-07-01), Scotese et al.
patent: 5037826 (1991-08-01), Blythin et al.
patent: 5620981 (1997-04-01), Blankley et al.
patent: 5733913 (1998-03-01), Blankley et al.
patent: 5945422 (1999-08-01), Doherty et al.
patent: 2005/0055513 (2002-05-01), Arzeno et al.
patent: 0 278 686 (1988-08-01), None
patent: 0 790 997 (2000-03-01), None
patent: WO 93/17682 (1993-09-01), None
patent: WO 96/34867 (1996-11-01), None
patent: WO 98/33798 (1998-08-01), None
patent: WO 99/61444 (1999-12-01), None
patent: WO 01/29041 (2001-04-01), None
patent: WO 02/064594 (2002-08-01), None
patent: WO 03/062236 (2003-07-01), None
Boschelli, et al, “Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines. Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors,”Journal of Med. Chem., (1998), pp. 4365-4377, vol. 41.
Klutchko, et al., “2-Substituted Aminopyrido[2,3-d] pyrimidin-7(8H)-ones. Structure-Activity Relationships Against Selected Tyrosine Kinases and In Vitro and in Vivo Anticancer Activity,”Journal of Med. Chem., (1998), pp. 3276-3292, vol. 41.
Barvian, et al., “Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases,”Journal of Med. Chem., (2000), pp. 4606-4616, vol. 43.
Hamby, et al., “Structure-Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors,”Journal Med. Chem., (1997), pp. 2296-2303, vol. 40.
Boehm and Adams, “New inhibitors of p38 kinase,”Expert Opinion on Therapeutic Patents, vol. 10:1 (2000), pp. 25-37.
Trumpp-Kallmeyer, et al., Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors,J. Medicinal Chemistry, vol. 41 (1998), pp. 1752-1763.

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