Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-24
2006-10-24
Tsang, Cecilia J. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S312000, C514S313000, C514S359000, C514S367000, C514S373000, C514S375000, C514S376000, C514S377000, C514S380000, C540S451000, C540S462000, C546S153000, C546S156000, C546S157000, C546S158000, C546S160000, C548S159000, C548S161000, C548S164000, C548S221000, C548S222000
Reexamination Certificate
active
07125893
ABSTRACT:
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula Iin which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z are as defined in the specification. The compounds are useful in treating malignant tumours, for example, ovarian, stomach, colon, breast, adeno-, head and neck carcinomas, acute lymphocytic and myelocytic leukemia. In addition, these compounds are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases such as psoriasis and arthritis. Methods of use and preparation of the compounds are also described.
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Buchmann Bernd
Hoffmann Jens
Klar Ulrich
Lichtner Rosemarie
Schwede Wolfgang
Robinson Binta
Schering AG
Tsang Cecilia J.
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