6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory ag

Details 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory ag 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory ag

1977-11-08

1980-05-06

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26023955R, 26023955D, 2603971, 26039745, C07J 7100, A61K 3158

Patent

active

042017785

ABSTRACT:
Novel 6-acyloxy-3,20-dioxo-1,4,6-pregnatrienes and 6-acyloxy-3,20-dioxo-4,6-pregnadienes, useful anti-inflammatory agents, are prepared by reaction of the corresponding 3,6,20-trioxo-1,4-pregnadiene or 3,6,20-trioxo-4-pregnene with an acyl halide or an acid anhydride in pyridine. Preferred anti-inflammatory agents are 6-alkanoyloxy-9.alpha.-halogeno-16-methyl-1,4,6-pregnatriene-3,20-diones. Also described are novel 6-oxo-9.alpha.-halogeno-16-substituted-1,4-pregnadienes, useful as intermediates in preparing the corresponding 6-acyloxy-1,4,6-pregnatrienes and which also exhibit anti-inflammatory activity per se.

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