6,9-bridged erythromycin derivatives

Details 6,9-bridged erythromycin derivatives 6,9-bridged erythromycin derivatives

1997-09-08

1998-07-14

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 29, 536 74, 536 186, C07H 1708, A61K 3170

Patent

active

057806055

ABSTRACT:
Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

REFERENCES:
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patent: 5631355 (1997-05-01), Asaka et al.
patent: 5635485 (1997-06-01), Agouridas et al.
patent: 5658888 (1997-08-01), Koga et al.
patent: 5712253 (1998-01-01), Lartey et al.
Journal of Antibiotics, vol. 37, No. 2, (1984), pp. 187-189, S. Morimoto et al., "Chemical Modification of Erythromycins. I. Synthesis and Antibacterial Activity of 6-O-Methylerythromycins A".
Journal of Antibiotics, vol. 43, No. 3 (1990), pp. 286-294, S. Morimoto et al., "Chemical Modification of Erythromycins. II. Synthesis and Antibacterial Activity of O-Alkyl Derivatives of Erythromycin A".

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