6,8-Disubstituted purine derivatives of 9-.beta.-D-ribofuranosyl

Details 6,8-Disubstituted purine derivatives of 9-.beta.-D-ribofuranosyl 6,8-Disubstituted purine derivatives of 9-.beta.-D-ribofuranosyl

1975-09-29

1977-11-15

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 28, C07H 1918, C07H 1920

Patent

active

040586596

ABSTRACT:
Compounds of formula ##STR1## wherein X is --NR.sub.1 R.sub.2, --Cl, --Br or SR; Y is --X, --OH or --NH.sub.2 ; Z is hydrogen or --NH.sub.2 ; and R' is hydrogen or C.sub.1 -C.sub.18 acyl; R being hydrogen, aryl, aralkyl, substituted aryl, substituted aralkyl, or C.sub.1 -C.sub.7 alkyl; and R.sub.1 and R.sub.2 being independently selected from the group consisting of hydrogen, phenyl, C.sub.7 -C.sub.10 aralkyl, C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.10 branched chain alkyl, C.sub.1 -C.sub.7 unsaturated alkyl or lower alkyl joined to form a 5 or 6-membered heterocyclic ring, with the proviso that when one of R.sub.1 and R.sub.2 are hydrogen, the other is not. The compounds variously exhibit phosphodiesterase inhibition, protein kinase activation, positive inotropic effects, adenyl cyclase inhibition and other biological activities.

REFERENCES:
patent: 3225029 (1965-12-01), Yamaoka
patent: 3712885 (1973-01-01), Weimann et al.
patent: 3872084 (1975-03-01), Jones et al.
patent: 3872098 (1975-03-01), Jones et al.

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