6,8-dimercaptooctanoic acid derivatives substituted at the 6-S a

Details 6,8-dimercaptooctanoic acid derivatives substituted at the 6-S a 6,8-dimercaptooctanoic acid derivatives substituted at the 6-S a

1999-03-30

2000-09-12

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514255, 544358, 544386, 558251, 558255, A61K 31225, A61K 31495, C07C32704, C07C32718, C07D295185

Patent

active

061179027

ABSTRACT:
The present invention provides 6,8-Dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical, wherein they correspond to the following formula (I): ##STR1## in which: R represents OR.sub.3 or ##STR2## R.sub.3 representing a hydrogen atom, a linear or branched alkyl radical, or a radical of the formula ##STR3## n being an integer from 1 to 10 and r' and r", which are identical or different, representing a hydrogen atom, a linear or branched alkyl radical or, taken together, form with the nitrogen atom, a nitrogen-containing heterocycle optionally substituted with an optionally substituted oxygen or nitrogen atom,

REFERENCES:
Quash, G et al "Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells" Biochem. J. vol. 305 pp. 1017-1025, 1995.

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