6,7-nonsubstituted and 6,7-disubstituted-3,4-dihydroxy benzopyra

Details 6,7-nonsubstituted and 6,7-disubstituted-3,4-dihydroxy benzopyra 6,7-nonsubstituted and 6,7-disubstituted-3,4-dihydroxy benzopyra

1989-06-02

1991-07-02

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549282, C07D31118

Patent

active

050287206

ABSTRACT:
The present invention relates to novel benzopyranone aci-reductone compounds of the formula I wherein X and Y are selected from the group comprising H (except that X and Y are not both H, unless otherwise indicated) Cl or other halogen, OH, a straight or branched C.sub.1 14 C.sub.6 alkyl or alkoxy group or phenyl or phenyloxy groups, such as, for example a phenyl or a tertiary butyl group. The invention also provides for compounds of the general formula I wherein X, Y.dbd.OCH.sub.2 O. ##STR1##

REFERENCES:
Antiplatelet Actions of Cyclic and Aci-Reductone Analogs of Clofibric Acid, Romstedt et al., The Pharmacologist, 24, 214 (Jul. 31, 1985).
Schank, K., Chem. Ber., 114:1958-1962 (1981).
"Synthesis of Aci-Reductones as a New Class of Potential Hypolipidemic Agents", Kim et al., 18th Graduate Student Meeting in Medicinal Chemistry, Purdue University, Jun. 16-18, 1985.
"Synthesis of Aci-Reductones as a New Class of Potential Hypolipidemic Agents", Kim et al., Biomedical High Technology, 1985 Conference, Ohio State University, Nov. 13-15, 1985.

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