Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-09-28
1995-01-10
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549510, C07D30514, A61K 31335
Patent
active
053807510
ABSTRACT:
The present invention provides paclitaxel derivatives of formula I ##STR1## in which R.sup.1 is --COR.sup.z in which R.sup.Z is RO-- or R;
REFERENCES:
patent: 4814470 (1989-03-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 5015744 (1991-05-01), Holton
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5248796 (1993-09-01), Chen et al.
patent: 5284865 (1994-02-01), Holton et al.
Gunda I. Georg et al, "Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-Chlorobenzoyl)-(2'R,3'S)-3'-phenylisoserinate) and Baccatin III 13-(N-benzoyl-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate)," Bioorganic and Medicinal Chemistry Letters, vol. 2, No. 4, pp. 295-298, 1992.
Gunda I. Georg et al, "Semisynthesis and Biological Activity of Taxol Analogues: Baccatin III 13-(N-benzoyl-(2'R,3'S)-3'-(p-toly)isoserinate), Baccatin III 13-(N-(p-toluoyl)-(2'R,3'S)-3'-(phenylisoserinate), Baccatin III 13-(N-benzoyl-2'R,3'S)-3'-(p-trifluoromethylphenyl)isoserinate), and Baccatin III 13-(N-( p-trifluoromethylbenzoyl)-(2'R,3'S)-3'-phenylisoserinate)," Bioorganic and Medicinal Chemistry Letters, vol. 2, No. 12, pp. 1751-1754, 1992.
Gunda I. Georg et al, "Synthesis of Biologically Active Taxol Analogues with Modified Phenylisoserine Side Chains," Journal of Medicinal Chemistry, vol. 35, pp. 4230-4237, 1992.
F. Gueritte-Voegelein et al., "Relationships between the Structure of Taxol Analogues and Their Antimitotic Activity," Journal of Medicinal Chemistry, 34, pp. 992-998, 1991.
D. G. I. Kingston, et al, "The Chemistry of Taxol, A Clinically Useful Antincancer Agent", Journal of Natural Products, 53, No. 1, pp. 1-12, 1990.
N. F. Magri and D. G. I. Kingston, "Modified Taxols. 2..sup.1 Oxidation Products of Taxol", J. Org. Chem., 51, pp. 797-802, 1986.
N. F. Magri and D. G. I. Kingston, "Modified Taxols, 4. Synthesis and Biological Activity of Taxols Modified in the Side Chain", Journal of Natural Products, 51, No. 2, pp. 298-306, 1988.
Iwao Ojima et al, "Efficient and Practical Asymmetric Synthesis of the Taxol C-13 Side Chain, N-Benzoyl-(2 R, 3 S)-3-phenylisoserine, and Its Analogues via Chiral 3-Hydroxy-4-aryl-.beta.-lactams through Chiral Ester Enolate-Imine Cyclocondensation," Journal of Organic Chemistry, vol. 56, pp. 1681-1683, 1991.
Iwao Ojima et al, "New and Efficient Approaches to the Semisynthesis of Taxol and Its C-13 Side Chain Analogs by Means of .beta.-Lactam Synthon Method," Tetrahedron, vol. 48, No. 34, pp. 6985-7012, 1992.
Iwao Ojima et al, "New and Efficient Routes to Norstatine and Its Analogs with High Enantiomeric Purity by .beta.-Lactam Synthon Method," Tetrahedron Letters, vol. 33, No. 39, pp. 5737-5740, 1992.
C. S. Swindell et al, "Biologically Active Taxol Analogues with Deleted A-Ring Side Chain Substituents and Variable C-2'Configurations," Journal of Medicinal Chemistry, 34, pp. 1176-1184, 1991.
M. A. Tius, et al, "Halogenated Cannabinoid Synthesis," Tetrahedron, vol. 49, No. 16, pp. 3291-3304, 1993.
Michel Biollaz and Jaroslav Kalvoda, "Reactions of Steroids with Dialkylaminosulfur Trifluorides. I. 11.beta.B-Hydroxysteroids.", Helvetica Chimica Acta, vol. 60, Fasc. 8, No. 263, pp. 2703-2710, 1977.
An abstract from Stony Brook Symposium on Taxol and Taxotere New Hope for Breast Cancer, May 14 and 15, 1993, G. N. Chmurny, et al, "Purification and 2D NMR Structure Determination of 6-.alpha.Hydroxtaxol, a Major Human Metabolite of Taxol,"pp. 48-49.
Chen Shu-Hui
Farina Vittorio
Kadow John
Roth Gregory
Bristol--Myers Squibb Company
Han William T.
Peabody John
Richter Johann
LandOfFree
6,7-modified paclitaxels does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 6,7-modified paclitaxels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6,7-modified paclitaxels will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-850930