6,7-disubstituted-2-aminotetralines and pharmaceutical compositi

Details 6,7-disubstituted-2-aminotetralines and pharmaceutical compositi 6,7-disubstituted-2-aminotetralines and pharmaceutical compositi

1996-04-29

1997-06-10

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560141, A61K 31225, C07C 6900

Patent

active

056376146

ABSTRACT:
6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of methoxy, acetoxy and fluoro; and R and R.sub.1, identical or different, are selected from the group consisting of hydrogen, ethyl, propyl, cyclopropylmethyl, 2-hydroxy-2-phenylethyl, 2-hydroxy-2-(4-methylphenyl)ethyl and 2-hydroxy-3-(4-methoxyphenoxy)propyl are endowed with immunomodulator activity.

REFERENCES:
patent: 4593042 (1986-06-01), Liang
Atwal et al "Substituted 1,2,3,4 Tetra Hydroaminonaphthols Anti Hypertensive Agents, Calcium Channel Blockers and Adrenergic Receptor Blockers With Calecholamine-Depleting Effects" J. Med. Chem. 30:627-635 (1987).
Ertel et al "Immunoprotective Effect of Calcium Channel Blocker on Macrophage Antigen Presentation Function, Major Histocompatability Class II Antigen . . . " Surgery 108:154-160 (1990).

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