6,7-disubstituted-2-aminotetralines active as immunomodulators a

Details 6,7-disubstituted-2-aminotetralines active as immunomodulators a 6,7-disubstituted-2-aminotetralines active as immunomodulators a

1997-06-09

1999-10-05

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

A61K 31225

Patent

active

059625252

ABSTRACT:
6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of methoxy, acetoxy and fluoro; and R and R.sub.1, identical or different, are selected from the group consisting of hydrogen, ethyl, propyl, cyclopropylmethyl, 2-hydroxy-2-phenylethyl, 2-hydroxy-2-(4-methylphenyl)ethyl and 2-hydroxy-3-(4-methoxyphenoxy)propyl are endowed with immunomodulator activity.

REFERENCES:
patent: 4593042 (1986-06-01), Liang
Atwal et al. "Substituted 1,2,3,4-tetrahydroaminonaphthol Anti-Hypertensive Agents, Calcium Channel Blockers and Adrenergic Receptor Blockers with Catecholamine-depleting Effects" J. Med. chem. 30:627-635, 1987.
Ertel et al. "Immunoprotective Effect of Calcium Channel Blocker on Macrophage Antigen Presentation function, Major Histocompatability class II Antigen . . . " Surgery 108:154-160, 1990.

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