6,7-disubstituted 1-cycloproply-1,4-dihydro-4-oxo-1,8-naphthyrid

Details 6,7-disubstituted 1-cycloproply-1,4-dihydro-4-oxo-1,8-naphthyrid 6,7-disubstituted 1-cycloproply-1,4-dihydro-4-oxo-1,8-naphthyrid

1985-12-31

1989-06-20

Warden, Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514300, 544362, 546123, A61K 3141, A61K 31436, C07D47104

Patent

active

048409545

ABSTRACT:
New 6,7-disubstituted-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carb oxy lic acids of the formula (I) ##STR1## in which X represents halogen or nitro and A represents ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined hereinbelow are disclosed as well as their usefulness as antibacterial agents.

REFERENCES:
patent: 4292317 (1981-09-01), Pesson
patent: 4341784 (1982-07-01), Matsumoto
patent: 4359578 (1982-11-01), Matsumoto
patent: 4448962 (1984-05-01), Irikura
patent: 4544658 (1985-10-01), Peterson
patent: 4563459 (1986-01-01), Grohe
patent: 4571396 (1986-02-01), Hutt
patent: 4616019 (1986-10-01), Chu
patent: 4649144 (1987-03-01), Matsumoto
patent: 4663457 (1987-05-01), Mich
patent: 4665079 (1987-05-01), Culbertson
Chemical Abstracts, (103) 1985, p. 581, Ref. Nr. 22617d; Columbus, Ohio, U.S.
Chemical Abstracts, JP-A-60 32 790 (Dainippon Pharm. Co., Ltd.) 02/19/1985, *Zusammenfassung*.
Pro-Drugs as Novel Druge Delivekry Systems, American Chem Society Sep. 10, 1984, p. 380.

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