Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-11-01
2005-11-01
McKenzie, Thomas C. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S275000, C544S331000, C544S333000
Reexamination Certificate
active
06960593
ABSTRACT:
The present invention relates to 2-(4-fluorophenyl)-3-(2-phenoxy-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo-[1,2-a]pyrazol-1-one, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, having the formula:and pharmaceutical compositions thereof, and methods for controlling the level of one or more inflammation inducing cytokines selected from the group consisting of, interleukin-1 (IL-1), Tumor Necrosis Factor-α(TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8), thereby controlling, mediating, or abating disease states affected by the level of extracellular inflammatory cytokines in humans.
REFERENCES:
patent: 3449359 (1969-06-01), Testa et al.
patent: 529153 (1972-10-01), None
Chantry, D., Emerging Drugs, 1999, Chapter 1, pp. 5-13.
Illei, G. G. et al., “Novel, non-antigen-specific therapeutic approaches to autoimmune/inflammatory diseases”, Current Opinion In Immunology, 2000, vol. 12, Issue 6, pp. 712-718.
Black, R. A. et al., “Agents that Block TNF-a Synthesis or Activity”,Annual Reports in Medlcinal Chemistry- 32, Chapter 24, Academic Press, Inc., 1997, pp. 241-250.
Clark Michael Philip
Laufersweiler Matthew John
Echler Sr. Richard S.
McKenzie Thomas C.
The Procter & Gamble & Company
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