6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S275000, C544S331000, C544S332000

Reexamination Certificate

active

11159662

ABSTRACT:
The present invention relates to 2-(4-fluorophenyl)-3-(2-phenoxy-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo-[1,2-a]pyrazol-1-one, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, having the formula:and pharmaceutical compositions thereof, and methods for controlling the level of one or more inflammation inducing cytokines selected from the group consisting of, interleukin-1 (IL-1), Tumor Necrosis Factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8), thereby controlling, mediating, or abating disease states affected by the level of extracellular inflammatory cytokines in humans.

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Graninger et al. Curr. Opin. Rhematol. 13(3) 209-13, 2001.
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Illei, G. G. et al., “Novel, non-antigen-specific therapeutic approaches to autoimmune/inflammatory diseases”,Current Opinion in Immunology, 2000, vol. 12, Issue 6, pp. 712-718.
Black, R. A. et al., “Agents that Block TNF-α Synthesis or Activity”,Annual Reports in Medicinal Chemistry-32, Chapter 24, Academic Press, Inc., 1997, pp. 241-250.

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