6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S275000, C544S212000, C544S296000, C544S331000

Reexamination Certificate



The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula:wherein R1is substituted aryl; R4is substituted or unsubstituted aryl or heteroaryl.

patent: 3449359 (1969-06-01), Testa et al.
patent: 20030134867 (2003-07-01), Clark et al.
patent: 529153 (1972-10-01), None
patent: WO 0157042 (2001-08-01), None
patent: WO 03024971 (2003-03-01), None
patent: WO 03023971 (2004-03-01), None
Illei, G. G. et al., “Novel, non-antigen-specific therapeutic approaches to autoimmune/inflammatory diseases”,Current Opinion in Immunology,2000, vol. 12, Issue 6, pp. 712-718.
Black, R. A. et al., “Agents that Block TNF-αSynthesis or Activity”,Annual Reports in Medicinal Chemistry-32,Chapter 24, Academic Press, Inc., 1997, pp. 241-250.
U.S. Appl. No. 10/246,214, Michael Philip Clark et al., filed Sep. 18, 2002.


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