6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones

Details 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones

1992-02-28

1993-01-19

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26120

Patent

active

051808340

ABSTRACT:
This invention relates to 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols of the formula ##STR1## wherein X is ##STR2## or loweralkyl; Y is hydrogen, halogen, loweralkyl, loweralkoxy, trifluoromethyl, nitro or amino; R is H when the bond between the oxygen atom and the carbon atom in question is a single bond; otherwise the dotted line signifies part of a double bond to the oxygen atom; R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen, loweralkyl or arylloweralkyl, or R.sub.2 and R.sub.3 taken together with the nitrogen atom form an optionally substituted heterocycle selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, imidazol-1-yl, 1-piperazinyl, said substituents being hydrogen or loweralkyl;4-substituted-1-piperazinyl of the formula ##STR3## R.sub.8 is hydrogen or --OH; R.sub.4 is hydrogen, loweralkoxycarbonyl or aryloxycarbonyl; Z is chlorine, bromine or fluorine; m is an integer of 1 to 4; n is an integer of 1 to 4 or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention display utility as antipsychotic agents and analgesic agents.

REFERENCES:
Lakhuich et al, Chemical Abstracts, vol. 110 (1988) No. 135, 125e.
Bianchi et al, Chemical Abstracts, vol. 79 (1973) No. 53,217p.
Barbulescu et al, Chemical Abstracts, vol. 55 (1961), 16515i.

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