6,7-dihalomelatonins

Details 6,7-dihalomelatonins 6,7-dihalomelatonins

1984-10-04

1986-09-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548493, C07D20918

Patent

active

046148078

ABSTRACT:
6,7-Dichloromelatonin and related compounds are ovulation inhibitors of the formula ##STR1## wherein R and R.sup.1 are individually F or Cl, R.sup.2 is C.sub.1-3 alkyl, including methyl, ethyl, n-propyl and isopropyl, and R.sup.3 is H or methyl.

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patent: 4053624 (1977-10-01), Hubner et al.
patent: 4087444 (1978-05-01), Flaugh et al.
M. A. Frohn et al, Life Sciences, vol. 27, pp. 2043-2046 (1980), Structure-Activity Relationship of Melatonin Analogues.
Flaugh et al., J. Med. Chem., 22, 63 (1979) (Flaugh II), Synthesis and Evaluation of the Antiovulatory Activity of a Variety of Melatonin Analogues.
Ying and Greep, Endocrinology, 92, 333 (1973), Inhibition of Ovulation by Melatonin in the Cyclic Rat.
Chu et al., ibid, 75, 238 (1964), An Inhibitory Effect of Melatonin on the Estrous Phase of the Estrous Cycle of the Rodent.
O. Yu. Magidson, et al., Chemical Abstracts, 63, 18192a (1965).

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