Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-12-12
2006-12-12
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S293000
Reexamination Certificate
active
07148231
ABSTRACT:
The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. The [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful in the treatment of cancer. Also disclosed are methods of making and using the novel polymorph, as well as pharmaceutical compositions containing the novel polymorph.
REFERENCES:
patent: 1 044 969 (2000-10-01), None
patent: WO 96/30347 (1996-10-01), None
patent: WO 99/55683 (1999-11-01), None
patent: WO 01/34574 (2001-05-01), None
Bubendorf Andre Gerard
Hennig Michael
Hidber Pirmin
Rimmler Goesta
Rohrer Franziska
Hoffmann-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
Truong Tamthom N.
Wildman David E.
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