6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and th

Details 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and th 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and th

1983-03-14

1984-09-11

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424274, 424285, 546196, 548425, 549457, A61K 3134, C07D30792

Patent

active

044709900

ABSTRACT:
Herein is disclosed compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 each is hydrogen or lower alkyl or R.sup.1 and R.sup.2 together form an alkylene of the formula (CH.sub.2).sub.n wherein n is an integer from 4 to 6, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the compounds and pharmaceutical compositions. The compounds exhibit dopamine-receptor stimulating activity in a mammal and are useful for treating hyperprolactinemia, galactorrhea, amenorrhea, impotence, Parkinsonism, diabetes, acromegaly, hypertension and other central nervous system disorders.

REFERENCES:
patent: 3929836 (1975-12-01), Fothergill et al.
patent: 4110339 (1978-08-01), Bach et al.
Holt et al., Chem. Abst. 14156c, vol. 64 (1966).
L. B. Shagalov et al., Chem. Abstr. 91, 56747v (1979) for Kim. Geterotsikl. Soedin, (3), 360 (1979).
L. B. Shagalov et al., Chem. Abstr. 89, 146703r (1978) for Khim, Geterotsikl. Soedin, (5), 634 (1978).

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