6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives

Details 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives

1980-12-11

1983-01-25

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

424177, 424250, 548427, 548451, 564194, 564428, A61K 3140, C07D20956

Patent

active

043703410

ABSTRACT:
Herein is disclosed compounds of the formula ##STR1## in which R.sup.1,R.sup.2,R.sup.3,R.sup.4 and R.sup.5 each is hydrogen or lower alkyl, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the compounds and pharmaceutical compositions. The compounds exhibit dopamine-receptor stimulating activity in a mammal and are useful for treating hyperprolactinemia, galactorrhea, amenorrhea, impotence, Parkinsonism, diabetes, acromegaly, hypertension and other central nervous system disorders.

REFERENCES:
The Merck Index, p. 568, Seventh Edition, (1960), Merck and Co., Rahway, N.J.
H. Cassebaum, Chemical Abstracts, 52:16084d, (1958).
L. B. Shagalov et al., Chem. Abstr. 91, 56747 v (1979) for Khim. Geterotsikl. Soedin, (3), 360, (1979).
L. B. Shagalov et al., Chem. Abstr. 89, 146703 r (1978) for Khim. Geterotsikl. Soedin, (5), 634 (1978).
Derwent Publications Ltd. Farmdoc 46000U, (1973); Farmdoc 24087B, (1979).

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