6,7,8,9-Tetrahydro-3H-benz(e)indol-7-amines and a method of dopa

Details 6,7,8,9-Tetrahydro-3H-benz(e)indol-7-amines and a method of dopa 6,7,8,9-Tetrahydro-3H-benz(e)indol-7-amines and a method of dopa

1981-10-19

1984-06-12

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

548427, A61K 3140, C07D20960

Patent

active

044541503

ABSTRACT:
Herein is disclosed compounds of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each is hydrogen or lower alkyl, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the compounds and pharmaceutical compositions. The compounds exhibit dopamine-receptor stimulating activity in a mammal and are useful for treating hyperprolactinemia, galactorrhea, amenorrhea, impotence, Parkinsonism, diabetes, acromegaly, hypertension and other central nervous system disorders.

REFERENCES:
patent: 4110339 (1978-08-01), Bach et al.
patent: 4212804 (1980-07-01), Coppola
patent: 4370341 (1983-01-01), Asselin et al.
L. B. Shagalov et al., Chem. Abstr., 91, 56747 v, (1979), for Khim. Geterotsikl. Soedin, (3), 360, (1979).
L. B. Shagalov et al., Chem. Abstr., 89, 146703 r, (1978), for Khim. Geterotsikl. Soedin, (5), 634, (1978).
Chem. Abs., vol. 69, No. 25, p. 96, Abs. No. 106400, Dec. 16, 1968.

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