Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-05-17
2009-11-24
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07622581
ABSTRACT:
This invention concerns the compoundsthe N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, whereinX is NR2, O, S, SO, SO2;R1is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1or Het2;n is 1, 2 or 3;R2is hydrogen, aryl substituted with a radical —COOR4; or R2is substituted C1-10alkyl, C2-20alkenyl or C3-7cycloalkyl;or R2is a radical of formula:—CpH2p—CH(OR14)—CqH2q—R15(b-3); —CH2—CH2—(O—CH2—CH2)m—OR14(b-4);—CH2—CH2—(O—CH2—CH2)m—NR5aR5b(b-5);-a1=a2-a3=a4- is —CH═CH—CH═CH—; —N═CH—CH═CH—; —CH═N—CH═CH—; —CH═CH—N═CH—; —CH═CH—CH═N— (c-5); wherein one of the hydrogen atoms in (c-1)-(c-5) is replaced by particular radicals;R3is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxycarbonyl, substituted carbonyl, methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1.
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Kesteleyn Bart Rudolf Romanie
Kindermans Natalie Maria Francisca
Peeters Annick Ann
Raboisson Pierre Jean-Marie Bernard
Surleraux Dominique Louis Nestor Ghislain
Chandrakumar Nizal S
Seaman D. Margaret
Tibotec Pharmaceuticals Ltd.
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